Monitoring Warfarin Therapy in Patients with Lupus Anticoagulants

Letters15 March 1998Monitoring Warfarin Therapy in Patients with Lupus AnticoagulantsStephan Moll, MD and Thomas L. Ortel, MD, PhDStephan Moll, MDMedizinische Fakultat Charite der Humboldt-Universitat zu Berlin; 13122 Berlin, GermanyDuke University Medical Center; Durham, NC 27710Search for more papers by this author and Thomas L. Ortel, MD, PhDMedizinische Fakultat Charite der Humboldt-Universitat zu Berlin; 13122 Berlin, GermanyDuke University Medical Center; Durham, NC 27710Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Manoharan asks about the Thrombotest, which was described by Owren in 1959 as an alternative to Quick's thromboplastin time (prothrombin time) for monitoring oral anticoagulant therapy [1]. The Thrombotest was designed to be sensitive to decreases in levels of all four vitamin K-dependent procoagulant factors (factors II, VII, IX, and X), whereas Quick's test was sensitive to decreases in levels of factors II, VII, and X only. The original Thrombotest reagent consisted of an active cephalin and a low-activity thromboplastin to activate both intrinsic and extrinsic pathways. In addition, the sample was diluted into adsorbed bovine plasma ...References1. Owren PA. Thrombotest. A new method for controlling anticoagulant therapy. Lancet. 1959; 2:754-8. Google Scholar2. Sise HS, Lavelle SM, Adamis D, Becker R. Relation of hemorrhage and thrombosis to prothrombin during treatment with coumarin-type anticoagulants. N Engl J Med. 1958; 259:266-71. Google Scholar3. Zivelin A, Rao LV, Rapaport SI. Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors. J Clin Invest. 1993; 92:2131-40. Google Scholar4. Le DT, Weibert RT, Sevilla BK, Donnelly KJ, Rapaport SI. The international normalized ratio (INR) for monitoring warfarin therapy: reliability and relation to other monitoring methods. Ann Intern Med. 1994; 120:552-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Medizinische Fakultat Charite der Humboldt-Universitat zu Berlin; 13122 Berlin, GermanyDuke University Medical Center; Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 504-505KeywordsAnimal modelsAnticoagulant therapyAnticoagulantsBlood plasmaFibrinogenPartial thromboplastin timePhospholipidsProthrombin time Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...