Stable stacking. DNA mimics have been prepared from simple, non-nucleosidic building blocks. These oligonucleotides, which contain extended stretches of phenanthrene derivatives, form stable hybrids. The phenanthrene residues contribute to the stability of the duplex through interstrand stacking interactions. The hybrids adopt an overall B-form structure, thus mimicking natural DNA.
No takes yet. Share an insight, caveat, or question.
Langenegger et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: