Key result
Timolol and brimonidine reduce maximum exercise heart rate by up to ~14 bpm vs placebo.
Why the study?
The cardiovascular effects of timolol 0.5%, brimonidine 0.2%, and their concomitant use on maximal exercise performance in young healthy volunteers were not well characterized.
Does timolol, brimonidine, or their combination alter maximal exercise performance and cardiovascular parameters in young healthy volunteers?
RCT (n=20)
Double-masked
Does timolol, brimonidine, or their combination alter maximal exercise performance and cardiovascular parameters in young healthy volunteers?
Absolute Event Rate: 186% vs 196%
p-value: p=< 0.005
Administration of timolol and brimonidine, alone or concomitantly, induces significant systemic cardiovascular effects including reduced maximal exercise heart rate and increased premature contractions in healthy volunteers.
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Topical timolol and brimonidine reduce maximal exercise heart rate; confirms systemic effects but applicability to older glaucoma patients remains uncertain.
Stewart et al. (2002) conducted an RCT in Healthy volunteers (n=20). Timolol, brimonidine, or timolol/brimonidine concomitant therapy vs. Placebo was evaluated on Mean maximum exercise heart rate (p=< 0.005). Timolol, brimonidine, and their combination significantly reduced mean maximum exercise heart rate compared to placebo (182, 187, and 186 bpm vs 196 bpm, respectively; p<0.005).
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