Key result
Anomalous retroaortic circumflex arteries develop earlier and greater atherosclerotic narrowing versus nonanomalous controls.
Why the study?
The anomalous origin of the circumflex coronary artery from the right sinus of Valsalva is usually considered benign, but its predisposition to accelerated atherosclerosis lacked convincing data.
Does an anomalous circumflex coronary artery predispose to accelerated atherosclerosis compared to normal coronary arteries?
Population
Patients with anomalous circumflex artery identified from 2,684 coronary angiography procedures between January 1998 and March 2000
Comparison
Atherosclerotic narrowing in anomalous circumflex artery vs other coronary arteries in same patients and nonanomalous circumflex arteries in matched controls
Design
Case-control study
Authors
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Supports targeted review of anomalous circumflex on angiography; leaves open accelerated atherosclerosis risk in larger cohorts.
Case-Control
No
Does an anomalous circumflex coronary artery predispose to accelerated atherosclerosis compared to normal coronary arteries?
Anomalous circumflex coronary arteries arising from the right side with a retroaortic course are predisposed to accelerated atherosclerosis, challenging the traditional view that this anomaly is entirely benign.
Samarendra et al. (2001) conducted a case-control in Anomalous circumflex coronary artery. Anomalous circumflex coronary artery vs. Nonanomalous circumflex arteries in matched controls and other coronary arteries in the same patient was evaluated on Degree of atherosclerotic narrowing. Anomalous circumflex coronary arteries with a retroaortic course exhibited earlier and greater atherosclerotic narrowing compared to nonanomalous arteries in matched controls.
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