Key result
Highest quartile of serum very long-chain omega-3 fatty acids linked to ~80% lower first MI risk.
Why the study?
The association between serum free fatty acid composition and risk of a first myocardial infarction was not well established.
Is the composition of serum free fatty acid fraction associated with the risk of a first myocardial infarction in men and postmenopausal women aged 45-75 years?
Population
103 patients with first MI and 104 population controls, men and postmenopausal women, age 45-75 years
Comparison
Higher versus lower percentage content of VLC n-3 and stearic acid in serum FFA fraction
Design
Case-control study
Authors
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Higher levels of very long-chain omega-3 fatty acids in the serum free fatty acid fraction are associated with a significantly decreased risk of first myocardial infarction.
Case-Control (n=207)
Yes
Is the composition of serum free fatty acid fraction associated with the risk of a first myocardial infarction in men and postmenopausal women aged 45-75 years?
Odds Ratio: 0.2 (95% CI 0.06–0.63)
Higher levels of very long-chain omega-3 fatty acids in the serum free fatty acid fraction are associated with a significantly decreased risk of first myocardial infarction.
Yli-Jama et al. (2002) conducted a case-control in First myocardial infarction (n=207). Highest quartile of total very long-chain omega-3 fatty acids (VLC n-3) in serum FFA vs. Lowest quartile of VLC n-3 in serum FFA was evaluated on First myocardial infarction (OR 0.20, 95% CI 0.06-0.63). The highest quartile of very long-chain omega-3 fatty acids in serum free fatty acids was associated with a decreased risk of first myocardial infarction (OR 0.20; 95% CI 0.06-0.63).