Rapid Formation of a Preoligomeric Peptide–Metal–Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

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CuII connects peptides: The mechanism of binding of CuII to amyloid β peptides (Aβ) implicated in Alzheimer's disease was elucidated by stopped-flow spectroscopy, NMR relaxation, and simulation of the kinetics on the millisecond timescale. Two monomeric Cu–Aβ species and a dimeric Aβ–Cu–Aβ species were identified (see picture). Aberrant aggregation apparently occurs from the monomeric species.