What question did this study set out to answer?

To determine whether acute hyperglycemia (fasting blood sugar) or chronic hyperglycemia (elevated HbA1c) is more strongly associated with increased morbidity and mortality following coronary artery bypass graft surgery.

May 9, 2013Annals of Thoracic and Cardiovascular SurgeryOpen Access

Hyperglycemia or High Hemoglobin A1C: Which One is More Associated with Morbidity and Mortality after Coronary Artery Bypass Graft Surgery?

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Authors

ZFZahra FaritousIran University of Medical Sciences MAMaryam ArdeshiriIslamic Azad University of Shahrekord FYForouzan YazdanianIran University of Medical Sciences

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Implication

Prospective study finds elevated blood sugar and HbA1c increase distinct post-CABG complications in surgical patients, highlighting the need for preoperative glycemic monitoring.

Key Points

To determine whether acute hyperglycemia (fasting blood sugar) or chronic hyperglycemia (elevated HbA1c) is more strongly associated with increased morbidity and mortality following coronary artery bypass graft surgery.
Prospective study of 216 patients undergoing elective coronary artery bypass graft (CABG) surgery.
Patients were stratified by baseline plasma HbA1c (>7% vs ≤7%) and fasting blood sugar (FBS >126 mg/dl vs ≤126 mg/dl).
Multivariate regression analyses evaluated associations between glycemic metrics and postoperative adverse events.
HbA1c >7% (n=51 vs n=165 ≤7%) significantly increased odds of postoperative re-intubation (OR 8.15, 95% CI 2.88–23.09, P=0.001), wound infection (OR 8.15, 95% CI 2.88–23.09, P=0.001), and bleeding (OR 2.18, 95% CI 1.10–4.35, P=0.027).
Hyperglycemia with FBS >126 mg/dl (n=87 vs n=129 ≤126 mg/dl) was associated with higher rates of arrhythmias (OR 3.07, 95% CI 1.69–5.59, P=0.001), atelectasis (OR 1.88, 95% CI 1.07–3.30, P=0.029), and wound infection (OR 8.75, 95% CI 2.45–31.25, P=0.001).
Elevations in HbA1c and FBS contributed significantly to postoperative morbidity but showed no significant association with mortality rates.

Cite This Study

Faritous et al. (2013) studied this question.

synapsesocial.com/papers/6aae1ef3f37176e322fef4b1 https://doi.org/10.5761/atcs.oa.13.02282

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Implication

Prospective study finds elevated blood sugar and HbA1c increase distinct post-CABG complications in surgical patients, highlighting the need for preoperative glycemic monitoring.

Hyperglycemia or High Hemoglobin A1C: Which One is More Associated with Morbidity and Mortality after Coronary Artery Bypass Graft Surgery?

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperglycemia or High Hemoglobin A1C: Which One is More Associated with Morbidity and Mortality after Coronary Artery Bypass Graft Surgery?

Discussion

Member takes

Implication

Key Points

Cite This Study

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