TRMT10C polymorphisms confer Wilms tumor predisposition: a five-center study

Wilms tumor is a prevalent childhood kidney cancer, which is known to be influenced by genetic predisposition. TRMT10C plays a role in RNA modification and mitochondrial function. This study explored the associations of four TRMT10C variants with susceptibility to Wilms tumor in Chinese children. This case‒control study included 414 cases diagnosed with Wilms tumor and 1199 controls. Four TRMT10C variants (rs7641261 C > T, rs2303476 T > C, rs4257518 A > G, and rs3762735 C > G) were genotyped by the TaqMan method. Logistic regression analyses were applied under multiple genetic models to determine the contributions of these genetic variants to Wilms tumor risk. None of the four TRMT10C variants was significantly associated with susceptibility to Wilms tumor. However, subgroup analysis revealed that the rs7641261 TT genotype enhanced the risk of Wilms tumor in boys and susceptibility to early-stage Wilms tumors. Moreover, individuals carrying multiple high-risk genotypes presented an elevated early-stage Wilms tumor predisposition. eQTL analysis demonstrated a significant correlation between the rs7641261 TT genotype and reduced transcript levels of SENP7. This study indicates that the TRMT10C rs7641261 polymorphism may confer Wilms tumor risk, particularly in boys and those with early-stage disease. These findings contribute to our comprehension of Wilms tumor's genetic basis.