Shedding new light on vitamin D and fatty liver disease

Vitamin D in its active form, 1,25-(OH)2 vitamin D, has been shown to play a role in various diseases, such as different types of infectious and autoimmune diseases as well as cancers [1]. It is estimated that one billion people worldwide are vitamin D deficient or insufficient [2]. Sources of vitamin D are diet and dietary supplements as well as endogenously synthesised vitamin D from 7-dehydrocholesterol following exposure to ultraviolet B radiation [1]. To achieve the biologically active form, vitamin D3 undergoes 25-hydroxylation in the liver and subsequent 1-hydroxylation in the kidneys [3].