Key result
COVID-19 infection may trigger delayed-onset warfarin-induced non-uremic calciphylaxis after renal recovery.
Why the study?
Non-uremic calciphylaxis is infrequently observed and its potential association with COVID-19 infection and warfarin treatment requires increased clinician awareness.
Case Report (n=1)
COVID-19 and delayed renal recovery may act as additional triggers for warfarin-induced non-uremic calciphylaxis in patients with multiple risk factors.
Herein we report a case of an obese female presenting with calciphylaxis after a prolonged hospital course due to COVID-19, with multiple complications including now-recovered acute renal failure and deep venous thrombosis requiring treatment with warfarin.Two months after discharge, she presented with new, painful, ulcerated plaques on the thighs and was diagnosed with calciphylaxis.Throughout the COVID-19 pandemic, cutaneous manifestations of SARS-CoV-2 infection have been increasingly characterized, yet non-uremic calciphylaxis is infrequently observed.Despite its rarity, our case highlights the importance of clinician awareness of the potential association of COVID-19 as an additional trigger for calciphylaxis, especially in patients with multiple risk factors.We also urge physicians to be aware of delayed onset in the presentation of calciphylaxis after renal recovery.
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Halle et al. (2022) conducted a case report in Calciphylaxis following COVID-19 and acute renal injury (n=1). COVID-19 infection and warfarin therapy was evaluated on Development of calciphylaxis. COVID-19 infection may serve as an additional trigger for warfarin-induced, non-uremic calciphylaxis, which can present with delayed onset after renal recovery.
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