Biophysical study reveals stable triplex conformations in three guanine repeats of human telomeric DNA, highlighting alternative structural intermediates alongside classic G-quadruplexes.
Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats.
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Koirala et al. (2011) studied this question.
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