Key result
Maternal pre-existing ASCVD linked to ~9% greater risk of offspring congenital malformations and neonatal complications.
Why the study?
The impact of maternal pre-existing ASCVD on neonatal and long-term offspring neurodevelopmental outcomes remains poorly understood.
Does maternal pre-existing ASCVD increase the risk of adverse neonatal and long-term offspring outcomes?
Cohort (n=5,461,222)
Yes
Does maternal pre-existing ASCVD increase the risk of adverse neonatal and long-term offspring outcomes?
Maternal pre-existing ASCVD is associated with modest but consistent increases in neonatal complications and early childhood neurodevelopmental disorders.
Answers are grounded in this paper and cite their sources.
May warrant enhanced neonatal monitoring in ASCVD pregnancies; leaves open causal pathways and preventive strategies.
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Heo et al. (2025) conducted a cohort in Maternal pre-existing atherosclerotic cardiovascular disease (n=5,461,222). Maternal pre-existing ASCVD vs. Mothers without pre-existing ASCVD was evaluated on Congenital malformations (aOR 1.09, 95% CI 1.07-1.12). Maternal pre-existing ASCVD was associated with increased risks of offspring congenital malformations, NICU admission, sepsis, and neurodevelopmental disorders.
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