Key result
Simulated redo TAVR in Asian patients demonstrated a risk for coronary obstruction due to sinus of Valsalva sequestration, associated with STJ dimensions and implantation depth (P<0.001).
Why the study?
Data are limited on the risk for coronary obstruction due to sinus of Valsalva sequestration in redo TAVR procedures in Asian patients.
Observational (n=1,122)
p-value: p=<0.001
A substantial number of Asian patients may be at risk for coronary obstruction during future redo TAVR, highlighting the importance of considering structural feasibility during the initial TAVR procedure.
May inform redo TAVR planning in Asian patients; leaves open prospective validation of simulation-derived risk.
Background: In the Asian cohort, data are limited on the risk for coronary obstruction due to sinus of Valsalva (SOV) sequestration in redo transcatheter aortic valve replacement (TAVR) procedures. Objectives: The aim of this study was to assess the potential risk for coronary obstruction in simulated redo TAVR in Asian patients. Methods: Post-TAVR computed tomographic data from 788 patients who received balloon-expandable (BE) SAPIEN 3 transcatheter aortic valves (TAVs) and 334 patients who received self-expanding (SE) Evolut R or Evolut PRO TAVs were analyzed. The risk for coronary obstruction due to SOV sequestration in redo TAVR, defined as the TAV commissure level above the sinotubular junction (STJ) and a TAV-to-STJ distance <2.0 mm in each coronary sinus, was retrospectively evaluated. Results: < 0.001). After adjusting for multiple covariates, STJ diameter, STJ height, TAV oversizing degree by area, and implantation depth were independently associated with SOV sequestration risk in the BE TAV group, whereas STJ diameter and implantation depth were independently associated with SOV sequestration risk in the SE TAV group. Conclusions: Coronary obstruction due to SOV sequestration in redo TAVR may occur in a substantial number of Asian patients. This finding suggests the importance of considering the structural feasibility of future redo TAVR when implanting the first TAV, especially in Asian patients with long life expectancy.
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Miyawaki et al. (2023) conducted an observational in Aortic valve disease requiring TAVR (n=1,122). Transcatheter aortic valve replacement (TAVR) was evaluated on Risk for coronary obstruction due to SOV sequestration in redo TAVR (p=<0.001). Simulated redo TAVR in Asian patients demonstrated a risk for coronary obstruction due to sinus of Valsalva sequestration, associated with STJ dimensions and implantation depth (P<0.001).
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