efficiently catalyzes phosphorylation, generating phosphorylated products at physiologically relevant concentrations. In phosphorylation reactions via phosphite oxidation, a portion of the energy released is conserved in phosphorylated products, as in biological energy conservation. Favorable thermodynamics of aqueous phosphite-dependent phosphorylation reactions suggest their possible involvement in the origin of metabolism.
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Hoffmann et al. (2026) studied this question.
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