What is the clinical evidence from this study?

Study design: Cohort. Population: Early-onset pre-eclampsia (n=380). Intervention: History of early-onset pre-eclampsia. Primary outcome: Recurrent delivery before 34 weeks of gestation (95% CI 12-22).

What does this research mean for the field?

Women with early-onset severe pre-eclampsia in their first pregnancy have a 17% recurrence risk of delivery before 34 weeks of gestation in a subsequent pregnancy, with only 32% experiencing a completely uneventful pregnancy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 4, 2011BJOG An International Journal of Obstetrics & Gynaecology

Recurrence risk and prediction of a delivery under 34 weeks of gestation after a history of a severe hypertensive disorder

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Key result

First-pregnancy early severe pre-eclampsia links to a ~17% risk of recurrent delivery before 34 weeks.

95% CI 12-22
n=380

Why the study?

Outcomes and risk factors for recurrence of early-onset pre-eclampsia and preterm delivery after a first pregnancy complicated by severe hypertensive disorder were not well characterized.

Population

380 women with early-onset pre-eclampsia delivering before 34 weeks in first pregnancy

Comparison

Subsequent pregnancy outcomes after early-onset pre-eclampsia

Design

Retrospective cohort study at two tertiary centres with regional function

Follow-up

Course of subsequent pregnancies

Authors

JLJosje LangenveldZuyderland Medisch Centrum ABA Buttinger JPJoris van der PostUniversity of Amsterdam

Discussion

Member takes

Implication

Supports intensified antenatal surveillance after early severe pre-eclampsia; leaves open whether targeted interventions reduce recurrent preterm delivery.

Study Design

Type

Cohort (n=380)

Multicenter

Yes

Structured PICO

Population

380 women with a history of early-onset pre-eclampsia in their first pregnancy, of whom 211 had a subsequent pregnancy evaluated for recurrence.

Outcome

Absolute risk of recurrence of an adverse outcome, defined as a hypertensive complication resulting in delivery before 34 weeks of gestation.hard clinical

Women with early-onset pre-eclampsia in their first pregnancy face a 17% risk of recurrent severe pre-eclampsia before 34 weeks in subsequent pregnancies, with chronic hypertension and proteinuria being independent predictors.

Cite This Study

Langenveld et al. (2011) conducted a cohort in Early-onset pre-eclampsia (n=380). History of early-onset pre-eclampsia was evaluated on Recurrent delivery before 34 weeks of gestation (95% CI 12-22). Women with early severe pre-eclampsia in their first pregnancy had a 17% risk (95% CI 12-22%) of recurrent delivery before 34 weeks of gestation in a subsequent pregnancy.

synapsesocial.com/papers/6aae23215dbd77d586e1c575 https://doi.org/10.1111/j.1471-0528.2010.02842.x

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Implication

Supports intensified antenatal surveillance after early severe pre-eclampsia; leaves open whether targeted interventions reduce recurrent preterm delivery.

Recurrence risk and prediction of a delivery under 34 weeks of gestation after a history of a severe hypertensive disorder

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Recurrence risk and prediction of a delivery under 34 weeks of gestation after a history of a severe hypertensive disorder

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider