Key result
Higher eGFR, but not serum creatinine, correlates with better MMSE scores in elderly CKD patients.
Why the study?
Cognitive impairment commonly occurs in individuals with CKD, and early diagnosis and intervention are important to decrease its progression, but the relation between serum creatinine, e-GFR, and cognition in elderly with normal muscle mass is unclear.
Cross-Sectional (n=45)
No
In elderly patients with CKD and normal muscle mass, eGFR is a better predictor of cognitive function than serum creatinine.
Supports link between higher creatinine and cognitive impairment in CKD; hypothesis-generating, needs prospective validation before practice change.
Background: Chronic kidney disease (CKD) and cognitive impairment are important and prevalent public health problems that lead to increase the risk of morbidity and mortality. Both are considered a major social and financial burden.Cognitive impairment commonly occurs in individuals with CKD; therefore cognitive assessment is extremely important. Early diagnosis and intervention help to decrease the progression of cognitive impairment.Aim: To identify the relation between serum creatinine level and estimated glomerular filtration rate (e-GFR) and global cognitive function (Mini Mental State Examination (MMSE) score in Egyptian elderly with CKD stages 2-4 with normal muscle mass.Methods: Cross-sectional study was conducted at the Geriatrics in-patient wards and outpatient clinics at Ain Shams University Hospitals, Cairo, Egypt, over six months. Fourty five elderly patients who had CKD stages 2-4 with normal muscle mass index were included in the study. Muscle mass was assessed using Bio Electrical Impedance analysis (BIA). History was taken from all participants followed by assessment of the global cognitive function by MMSE, measurement of the serum creatinine level and e-GFR by 24 hours urinary creatinine clearance.Results: There was a significant negative correlation between serum creatinine level and MMSE score, and a significant positive correlation between e-GFR and MMSE score. By regression analysis of possible confounding factors, only e-GFR not serum creatinine level shows a significant correlation with MMSE. Conclusion: e-GFR not serum creatinine level is associated with a lower MMSE score in elderly despite having normal muscle mass.
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Sayed et al. (2019) conducted a cross-sectional in Chronic kidney disease (CKD) stages 2-4 (n=45). Estimated glomerular filtration rate (e-GFR) and serum creatinine level was evaluated on Global cognitive function assessed by Mini Mental State Examination (MMSE) score. Estimated glomerular filtration rate, but not serum creatinine level, showed a significant positive correlation with MMSE scores in elderly patients with CKD stages 2-4 and normal muscle mass.
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