Key result
Growth hormone replacement shows early evidence of improving vigor and well-being in deficient adults.
Why the study?
The biological relevance of growth hormone in adults and the effects of GH replacement in adults with GH deficiency have become important areas of investigation.
May justify symptomatic use in select adults; leaves open randomized confirmation of long-term outcomes.
Until the last decade most physicians considered growth hormone (GH) to have no biological relevance following the cessation of linear growth. The first evidence that GH is important throughout adult life came from a report, in which a 35-year-old hypopituitary adult described increased vigor, ambition, and well-being, following GH replacement (1). Recombinant technology resulting in a limitless supply of GH has prompted intensive investigation of the effects of GH in health and disease, and the effects of GH replacement in adults with GH-deficiency has received particular attention.
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Carroll et al. (1989) conducted a review in Growth Hormone Deficiency. Growth hormone replacement was evaluated. Growth hormone replacement in adults with growth hormone deficiency has become an area of intensive investigation following early evidence of improved vigor and well-being.
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