Key result
Amiodarone paradoxically accelerates ventricular rate to 280 bpm during AF in a WPW patient.
Why the study?
The effects of amiodarone on ventricular rate and arrhythmia risk in WPW syndrome during atrial fibrillation are not fully understood.
Does amiodarone therapy cause paradoxical malignant ventricular arrhythmias in patients with Wolff-Parkinson-White syndrome?
Comparison
Amiodarone therapy effect on ventricular arrhythmia
Design
Case report
Authors
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Amiodarone may aid ventricular rate control in WPW; leaves open need for prospective trials before practice change.
Case Report (n=1)
Does amiodarone therapy cause paradoxical malignant ventricular arrhythmias in patients with Wolff-Parkinson-White syndrome?
Amiodarone may paradoxically increase ventricular rate during atrial fibrillation in patients with Wolff-Parkinson-White syndrome, potentially leading to malignant ventricular arrhythmias.
Perticone et al. (1987) conducted a case report in Wolff-Parkinson-White (WPW) syndrome (n=1). Amiodarone was evaluated on Ventricular rate and minimum R-R interval during atrial fibrillation. Amiodarone therapy in a young male with WPW syndrome paradoxically worsened ventricular response during atrial fibrillation, increasing ventricular rate from 210 to 280 beats/min.
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