To Evaluate the Efficacy and Safety of Autologous Platelet Rich Fibrin Matrix in the Treatment of Non-Healing Ulcer of Various Aetiology

extraction [3] and transplant on the wound bed, epidermal grafting, etc.Recently, the focus has shifted on to growth factors which include therapies like recombinant growth factors and Platelet Rich Plasma (PRP).Platelet Rich Fibrin Matrix (PRFM), a next generation PRP is the latest addition which is based on the premise of slow and sustained release of growth factors [4] mimicking the natural wound healing process.The concentration of platelets is higher in PRP but a study showed that, when incorporated into fibrin, the mean concentration of growth factors in the platelet concentrates was three times or more than that observed with conventional platelet-rich plasma.The membrane can be easily placed on the ulcer with minimal chances of displacement.Thus giving PRFM an edge over PRP in wound healing.Autologous PRFM is prepared from patients own blood thus being free from risk of communicable pathogens, is easy to prepare with long lasting as well as good clinical results.