Key result
MCT1 AA genotype linked to higher total and bone injury rates in male rugby players.
Why the study?
Several genes are involved in sport performance and injury incidence, but the genotype/phenotype correlation in rugby players was not well established.
Is there an association between ACE, ACTN3, COL1A1, and MCT1 genotypes and the incidence of injuries in male rugby players?
Observational (n=200)
Is there an association between ACE, ACTN3, COL1A1, and MCT1 genotypes and the incidence of injuries in male rugby players?
p-value: p=0.003
The MCT1 AA genotype is associated with an increased incidence of total and bone injuries in male rugby players, suggesting a potential role for genetic profiling in developing personalized training programs.
MCT1 AA genotype may flag higher injury risk in male rugby players; hypothesis-generating and should not yet inform screening or training changes.
Several genes are involved in sport performance, especially in injuries incidence. The aim of this study was to investigate the association of ACE, ACTN3, COL1A1, and MCT1 genotypes and injuries in rugby players in order to find a genotype/phenotype correlation and provide useful information improving athletic performance. One-hundred male professional and semiprofessional rugby players were selected. Analysis was performed genotyping the genes ACE, ACTN3, COL1A1, and MCT1 as candidate gene of interest involved in athletic performance. A control group of non-athletic Italian male participants was analyzed to compare the results. We found statistical significance of MCT1 rs1049434 AA for total injuries (χ2 = 0.115; p = 0.003) and bone injuries (χ2 = 0.603; p = 0.007) in the rugby athlete population. No statistical significance was found between injury incidence and ACE, ACTN3, COL1A1 genotypes. The MCT1 AA genotype is associated with the incidence of total and bone injuries in the rugby player population. Although environmental factors such as lifestyle, diet, training, and stress can influence athletic performance, our data demonstrated the importance of genetic study in sport aimed at developing personalized training and achieving the best possible athletic excellence.
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Onori et al. (2022) conducted an observational in Sport injuries (n=200). MCT1 AA genotype vs. MCT1 AT and TT genotypes was evaluated on Incidence of total injuries (p=0.003). The MCT1 AA genotype was significantly associated with a higher incidence of total injuries (p = 0.003) and bone injuries (p = 0.007) in male rugby union players.
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