Assessment of Haematological Complications and Prognostic Value of Oxidative Stress Markers in Viral Hepatitis B Patients

Background and Objective: Viral hepatitis infection could develop several complications include chronic infection, acute or sub-acute hepatic necrosis, cirrhosis, liver failure and hepatocellular carcinoma.The goal of this study was to estimate the effect of viral hepatitis B infection on some haematological and oxidative stress markers in men patients.Materials and Methods: Thirty voluntary men from the El Oued region divided equally into hepatitis B patients and control groups.Prediction tests of oxidative stress markers were estimated using ROC curve analysis.Results: Results showed that the leukocytes and platelet lines cells were significantly increased (p<0.01) but the erythrocyte line was significantly decreased (p<0.05) in the hepatitis group as compared to the control group.In this experimental study, the result showed a significant increase (p<0.001) of serum MDA level, SOD and catalase activities, also a significant decrease (p<0.001) of serum GSH in the hepatitis group compared to the control group.ROC analysis indicated that all of MDA and GSH levels, SOD and catalase activities were a high specificity and important AUC percentage with high correlation with risk factors of hepatitis B. Conclusion: Results indicated that, hematotoxicity and change in oxidative stress markers were the origins of the severity of hepatitis B infection.In addition, MDA, SOD, GSH and catalase were considered important diagnostic tools for follow up and predicting complications of hepatitis B.