Key result
Blood pressure, serum cholesterol, and smoking are independently linked to higher CHD risk over 25 years.
Why the study?
Long-term risk factors for coronary heart disease in initially healthy middle-aged men were not fully characterized over 25 years of follow-up.
What are the independent risk factors for coronary heart disease over a 25-year follow-up in 50-year-old men?
Cohort (n=845)
What are the independent risk factors for coronary heart disease over a 25-year follow-up in 50-year-old men?
Blood pressure, serum cholesterol, and smoking are independent risk factors for CHD over 25 years, with blood pressure remaining the sole independent predictor in the later stages of follow-up.
Supports sustained risk factor assessment in middle-aged men; leaves open causal effects and intervention benefits from observational data.
We followed 845 50-year-old men initially free of coronary heart disease (CHD) for 25 years. Blood pressure, serum cholesterol and smoking habits were significant and independent risk factors for CHD during the first 15 years of follow-up and for the whole follow-up period. CHD during the last 10 years of follow-up could be predicted by blood pressure, serum cholesterol and triglycerides and also by body mass index, but not by smoking habits in univariate analyses. Only blood pressure was an independent risk factor for CHD during the last 10 years of follow-up in multivariate analysis.
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Welin et al. (2008) conducted a cohort in Coronary Heart Disease (n=845). Cardiovascular risk factors (blood pressure, serum cholesterol, smoking) was evaluated on Coronary heart disease (CHD). Blood pressure, serum cholesterol, and smoking habits were significant independent risk factors for coronary heart disease over 25 years of follow-up.
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