Key result
Therapeutic hypothermia and bystander CPR benefit cardiac arrest patients alongside prognostic cell-free plasma DNA.
Why the study?
Recent data on cardiac arrest and cardiopulmonary resuscitation, including therapeutic hypothermia and other resuscitation strategies, were published in 2010 and require summarization.
This 2010 year-in-review provides a summary of key research developments in cardiac arrest and resuscitation, focusing on therapeutic hypothermia and prognostic markers.
Supports hypothermia and bystander CPR in arrest; leaves open validation of cell-free DNA as prognostic marker.
This review will summarize some of the data published in 2010 and focus on papers published in Critical Care in regard to cardiac arrest and cardiopulmonary resuscitation. In particular, we discuss the latest research in therapeutic hypothermia after cardiac arrest, including methods of inducing hypothermia, potential protective mechanisms, spontaneous hypothermia versus therapeutic hypothermia, and several predictors of outcome. Furthermore, we will discuss the effects of bystander-initiated cardiopulmonary resuscitation (CPR) in patients with physician-assisted advanced cardiac life support, the role of hypercapnea in near-death experiences during cardiac arrest, markers of endothelial injury and endothelial repair after CPR, and the prognostic value of cell-free plasma DNA as a marker of poor outcome after cardiac arrest.
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Metzger et al. (2011) conducted a review in Cardiac arrest and cardiopulmonary resuscitation. Resuscitation and post-resuscitation care was evaluated. Research in 2010 highlighted the benefits of therapeutic hypothermia and bystander-initiated CPR, as well as the prognostic value of cell-free plasma DNA in cardiac arrest patients.
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