What question did this study set out to answer?

To determine how nutritional status and fasting influence the gene expression of ghrelin in the stomach and its receptor in the hypothalamus and pituitary gland.

July 18, 2003Neuroreport

Changes in ghrelin and ghrelin receptor expression according to feeding status

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Authors

MKMin‐Seon KimUlsan College CYCho-Ya YoonUlsan College KPKyeong-Han ParkKangwon National University

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Implication

Animal experiment demonstrates increased ghrelin and ghrelin receptor expression in fasted rats, suggesting amplified appetite signaling during negative energy balance.

Key Points

To determine how nutritional status and fasting influence the gene expression of ghrelin in the stomach and its receptor in the hypothalamus and pituitary gland.
Measured stomach ghrelin mRNA and brain ghrelin receptor mRNA in rats subjected to fed, 48-hour fasted, or re-fed conditions.
Stomach ghrelin mRNA levels increased after 48 hours of fasting and decreased following re-feeding.
Ghrelin receptor mRNA levels in 48-hour fasted rats were 8 times higher in the hypothalamus and 3 times higher in the anterior pituitary gland compared to fed controls.

Cite This Study

Kim et al. (2003) studied this question.

synapsesocial.com/papers/6aae3b2f25e14290cc566f68 https://doi.org/10.1097/01.wnr.0000078703.79393.d2

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Implication

Animal experiment demonstrates increased ghrelin and ghrelin receptor expression in fasted rats, suggesting amplified appetite signaling during negative energy balance.

Changes in ghrelin and ghrelin receptor expression according to feeding status

Discussion

Member takes

Implication

Key Points

Cite This Study

Changes in ghrelin and ghrelin receptor expression according to feeding status

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider