Key result
Hyperoxygenation cuts surgical site infections ~55% versus lower oxygen levels in elective surgeries.
Why the study?
The influence of hyperoxygenation on surgical site wound infections was assessed due to uncertainty about its effect on infection rates and hospital stay.
Does hyperoxygenation (FiO2 60%) reduce surgical site wound infection in patients undergoing elective surgery?
RCT (n=100)
Randomized
No
Does hyperoxygenation (FiO2 60%) reduce surgical site wound infection in patients undergoing elective surgery?
Hyperoxygenation (FiO2 60%) during and for 3 hours after elective surgery significantly reduces surgical site infections and hospital stay duration.
Supports 60% FiO2 use in elective general surgery to cut infections; extends RCT evidence for perioperative hyperoxygenation.
Background: The aim of this study was to assess the influence of hyperoxygenation on surgical site wound infections.Methods: Using prospective randomized study, conducted from January 2018 to December 2018 at Mamata Medical College and General hospital, Khammam. This study includes 100 patients who were going for elective surgery at various divisions of Department of surgery. Patients were assigned randomly to an oxygen/air mixture with a faction of inspiration (FiO2) of 30% (n=50) and 60% (n=50). Administration was started after induction of anaesthesia and maintained for 3hours after surgery.Results: Surgical site infection was recorded in 5 patients (2 of 50, 10%) in the hyperoxygenation group and 11 patients (11 of 50, 22%) in the control group (p<0.05). Time of hospitalization was 5±3 days in the hyperoxygenation group and 9±4 days in the control group (p<0.05).Conclusions: Hyperoxygenation was associated with a reduction in surgical site infection. It also decreases the duration of hospital stay and decreases economic burden.
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G. et al. (2019) conducted an RCT in Elective general surgery (n=100). Hyperoxygenation vs. 30% FiO2 was evaluated on Surgical site infection (p=<0.05). Hyperoxygenation with 60% FiO2 significantly reduced the incidence of surgical site infections to 10% compared to 22% with 30% FiO2 in patients undergoing elective general surgeries.
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