Key result
Voltage-gated sodium channels regulate cardiovascular and nervous system action potentials via inactivation-mediated negative conductance.
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Design
Other
DIV S4 movement initiates NaV inactivation; extends gating models but leaves clinical translation for arrhythmias open.
Voltage-gated sodium channels play a central role in action potential firing throughout the cardiovascular and nervous systems, and their gating is exquisitely sensitive to changes in transmembrane potential. Negative regulation of sodium channel conductance occurs through a process known as
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Christopher A. Ahern (2013) studied this question. Voltage-gated sodium channels regulate action potentials in the cardiovascular and nervous systems, with their conductance negatively regulated through a process known as inactivation.
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