Synthesis of 1,2 dilinoleoyl and 1,2 dipalmitoylsn‐3‐glycerophosphorylcholine

The synthesis of 1,2 dilinoleoylsn‐3‐glycerophosphorylcholine (1,2‐18∶2‐sn‐3‐GPC) and 1,2 dipalmitoylsn‐3‐glycerophosphorylcholine (1,2‐16∶0‐sn‐3‐SPC) is described. Synthesis was accomplished by acylating free glycerophosphorylcholine (GPC) with the anhydride and potassium salt of the desired acid. Purification of 1,2‐16∶0‐sn‐3‐GPC was accomplished by crystallization, while purification of 1,2‐18∶2‐sn‐3‐GPC required the use of alumina column chromatography and then crystallization from acetone at −7C.