Key result
Sevoflurane and isoflurane reduce middle cerebral artery flow velocity without altering intracranial pressure or EEG.
Why the study?
The concentration-related effects of sevoflurane and isoflurane on cerebral physiology and plasma inorganic fluoride concentrations in neurosurgical patients were not fully characterized.
Does sevoflurane compared to isoflurane affect cerebral physiology and plasma inorganic fluoride concentrations in neurosurgical patients?
Population
14 neurosurgical patients
Comparison
Sevoflurane vs isoflurane at 0.5, 1.0, and 1.5 MAC with mannitol
Design
Physiological cohort study measuring cerebral parameters and plasma fluoride
Follow-up
Up to 72 hours postoperatively
Authors
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Characterizes dose-dependent cerebral effects of volatiles; leaves open optimal agent selection in neurosurgical patients.
Does sevoflurane compared to isoflurane affect cerebral physiology and plasma inorganic fluoride concentrations in neurosurgical patients?
Sevoflurane decreases middle cerebral artery flow velocity without increasing intracranial pressure or causing epileptiform EEG activity, suggesting its physiological effects are suitable for neurosurgery.
Artru et al. (1997) studied Neurosurgical patients (n=14). Sevoflurane vs. Isoflurane was evaluated on Middle cerebral artery flow velocity, intracranial pressure, electroencephalogram activity, and plasma inorganic fluoride concentrations. Sevoflurane and isoflurane decreased middle cerebral artery flow velocity without significantly altering intracranial pressure or causing epileptiform EEG activity in neurosurgical patients.
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