Key result
Obesity in young men is linked to ~15% higher cardiac output and lower peripheral blood flow.
Why the study?
Obesity in young adults is increasing and directly affects cardiovascular health, leading to early hypertension, dyslipidaemia, and peripheral vascular diseases.
Does increased BMI alter cardiac output and peripheral blood flow in healthy young adult males?
Cross-Sectional (n=90)
No
Does increased BMI alter cardiac output and peripheral blood flow in healthy young adult males?
In healthy young adult males, obesity is associated with increased cardiac output but decreased peripheral blood flow, suggesting early hemodynamic alterations and potential endothelial dysfunction.
Answers are grounded in this paper and cite their sources.
BMI association with cardiac output in young males is hypothesis-generating; leaves open causal or prognostic implications.
Introduction: Obesity is increasing at an alarming rate in young population which has a direct effect on their cardiovascular health resulting in development of hypertension, dyslipidaemia and peripheral vascular diseases at an early stage of life. Aim: To determine association of BMI with cardiac output and peripheral blood flow in young adult males. Materials and Methods: The study was a cross-sectional study done in Department of Physiology, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, India, between August to September 2015 under ICMR STS project. A total of 90 males with age 17-25 years with no history of smoking, alcoholism, diabetes mellitus, hypertension, cardiovascular or respiratory diseases were enrolled. BMI (kg/m2 ) was calculated and equal numbers of subjects were categorised into three groups according to BMI (South Asian Standards). Non obese (BMI <22.9 kg/m2 ), Overweight (BMI between 23- 24.9 kg/m2 ) and Obese (BMI ≥25 kg/m2 ). Cardiac output and peripheral blood flow of forearm and calf were measured using Non Invasive Continuous Cardiac Output and Peripheral Blood Flow Monitor (NIVOMON) series. The data were analysed statistically by using one-way ANOVA test. Results: Cardiac output was significantly more in obese group compared to overweight and normal BMI group (5.7±0.43 vs. 5.26±0.54 vs. 4.95±0.65 L/min, p<0.01). Forearm and calf blood flow of both limbs were significantly less in obese group compared to overweight and normal (p<0.01). Conclusion: Obese subjects have increased cardiac output which may lead to cardiac complications like left ventricular hypertrophy and high output cardiac failure in future. Inspite of increased cardiac output, peripheral blood flow was decreased in obese subjects which may be due to endothelial dysfunction and accelerated atherosclerotic vasoconstriction which may result in peripheral artery disease in future.
No takes yet. Share an insight, caveat, or question.
Garg et al. (2018) conducted a cross-sectional in Obesity (n=90). Obesity (BMI ≥25 kg/m2) vs. Normal BMI (<22.9 kg/m2) and Overweight (23-24.9 kg/m2) was evaluated on Cardiac output (p=<0.01). Obesity in young adult males was associated with significantly higher cardiac output (5.7 vs 4.95 L/min) and lower peripheral blood flow compared to normal BMI (p<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: