Obesity and increased body size were significantly associated with increased cardiac output (p<0.01) and stroke volume (p<0.01), as well as impaired multichamber myocardial strain.
Observational (n=57)
Obesity is associated with increased cardiac output and impaired multichamber strain on CMR, indicating early subclinical cardiovascular remodeling.
p-value: p=<0.01
BACKGROUND: To improve management of cardiovascular-kidney-metabolic syndrome, a better understanding of the early effects of body size on the heart is crucial and remains under investigation, considering the increasing global prevalence of obesity. Most data available on cardiovascular haemodynamics come from echocardiography despite the known challenges in image acquisition in the context of overweight and obesity. Using cardiac magnetic resonance imaging, we aimed to further investigate the effect of body size on cardiac output (CO) and other early imaging biomarkers of cardiovascular disease. METHOD: Participants including healthy volunteers and individuals with obesity who were planning to undergo bariatric surgery were recruited from two completed studies. The participants underwent cardiac magnetic resonance imaging. Measures of cardiovascular haemodynamics and myocardial mechanics were collected, including CO, stroke volume, heart rate, chamber volumes, and myocardial strain. The relationship of these variables with body size were assessed. RESULTS: A total of 57 participants were recruited (79% female; mean age, 41 years). A positive linear relationship was observed between CO vs body mass index (BMI) (p<0.01) and body surface area (BSA) (p<0.01). A similar trend was seen with stroke volume vs BSA (p<0.01) and BMI (p<0.01). Indexation to BSA rendered chamber volumes similar. We found significant differences in left and right atrial strain between the groups. Regression analysis demonstrated an association between left ventricular global longitudinal strain and right atrial strain with BSA and between left ventricular global longitudinal strain, right ventricular free wall strain, and right atrial strain with BMI. CONCLUSIONS: Obesity is associated with increased CO; this increase is a result of cardiac remodelling and consequent increase in stroke volume. Obesity is associated with an impairment of subclinical markers of cardiovascular disease measured using multichamber strain.
Madronio et al. (2025) conducted an observational in Obesity (n=57). Obesity and increased body size (BMI and BSA) vs. Healthy volunteers was evaluated on Relationship between cardiac output and body mass index or body surface area (p=<0.01). Obesity and increased body size were significantly associated with increased cardiac output (p<0.01) and stroke volume (p<0.01), as well as impaired multichamber myocardial strain.