Key result
Obesity is linked to impaired LV diastolic function, marked by a ~35% lower E/A ratio.
Why the study?
Obesity is a significant risk factor for cardiovascular disease, and this study aimed to determine its effect on left ventricular systolic and diastolic functions using echocardiographic indices.
Does obesity alter left ventricular systolic and diastolic functions based on echocardiographic indices in healthy adults without other comorbidities?
Population
75 obese and 75 averagely built subjects without comorbidities
Comparison
Obese subjects vs averagely built subjects
Authors
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Obesity-associated diastolic changes in healthy adults remain hypothesis-generating; prospective studies needed before any clinical implications.
Cross-Sectional (n=150)
Single-blind
No
Does obesity alter left ventricular systolic and diastolic functions based on echocardiographic indices in healthy adults without other comorbidities?
Absolute Event Rate: 0.81% vs 1.24%
p-value: p=0.001
Increased BMI is associated with subclinical alterations in left ventricular systolic and diastolic functions, including increased ventricular volumes and reduced ejection fraction, even in the absence of other comorbidities.
Gade et al. (2023) conducted a cross-sectional in Obesity (n=150). Obesity (BMI > 25 kg/m2) vs. Non-obese (BMI < 25 kg/m2) was evaluated on Early to late diastolic filling velocity (E/A) ratio (p=0.001). Obesity significantly impaired left ventricular diastolic function compared to non-obese controls, evidenced by a reduced E/A ratio (0.81 vs 1.24, p=0.001) and increased end-diastolic volume.
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