Key result
[99mTc]Tc-HMDP SPECT/CT shows ~5-fold higher LV MBR in ATTR versus non-ATTR cardiomyopathy.
Why the study?
The diagnostic utility of [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio for detecting ATTR cardiomyopathy required validation.
Does [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio accurately detect ATTR cardiomyopathy in patients with suspected disease?
Observational (n=80)
Yes
Does [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio accurately detect ATTR cardiomyopathy in patients with suspected disease?
The [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio provides a highly accurate, quantitative method for diagnosing ATTR cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Supports quantitative [99mTc]Tc-HMDP SPECT/CT for ATTR differentiation; hypothesis-generating and requires prospective validation.
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Hippeläinen et al. (2025) conducted an observational in Suspected ATTR cardiomyopathy (n=80). ATTR cardiomyopathy vs. Non-ATTR patients was evaluated on Left ventricular myocardium-to-blood ratio (LV MBR) (p=<.001). Left ventricular myocardium-to-blood ratio on [99mTc]Tc-HMDP SPECT/CT was significantly higher in ATTR cardiomyopathy patients compared to non-ATTR patients (4.6 vs 0.9, P<0.001).
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