Key result
Cardiac ATTR uptake on scintigraphy is linked to higher CV mortality in elderly HF patients.
Why the study?
The prognostic value of 99mTc-HMDP scintigraphy for cardiac transthyretin amyloidosis in elderly patients with chronic heart failure was unclear.
Observational
Yes
Answers are grounded in this paper and cite their sources.
Incidental cardiac uptake may flag higher CV mortality risk in elderly HF; leaves open independent prognostic value beyond clinical factors.
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Uusitalo et al. (2022) conducted an observational in Chronic heart failure. Cardiac uptake on 99mTc-HMDP scintigraphy (positive for ATTR) vs. No cardiac uptake was evaluated on Overall and cardiovascular mortality. Cardiac uptake suggestive of ATTR on 99mTc-HMDP scintigraphy was an independent predictor of cardiovascular mortality, but not overall mortality, in elderly heart failure patients.
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