Key result
GCRP guidelines integrate into routine ICU research with minimal extra time and effort.
Why the study?
Increasing clinical research in intensive care units necessitates understanding and applying Good Clinical Research Practice to ensure ethical and reliable studies.
This article outlines the principles of Good Clinical Research Practice and how they can be integrated into intensive care unit research.
Supports GCRP integration in ICU research with minimal burden; leaves open effects on trial quality and outcomes.
With the growing quest for answers to vexing dilemmas in critically ill patients, more intensive care units are embarking on clinical research. This places increasing importance on Good Clinical Research Practice (GCRP), a set of guidelines drawn up by the Pharmaceutical Industry to assist investigators in conducting ethical, reliable scientific studies. GCRP is a combination of good basic management skills allied to ethical principles for scientific research. Based on the principles of the Declaration of Helsinki, it consists of three tenets: patient protection (ethics), credible data (science) and data control. This article describes GCRP specifically relating it to the intensive care situation, illustrating some of the concepts with practical examples. With a minimum of extra time and effort these basic principles can be integrated as routine into all research projects.
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Scribante et al. (1998) conducted a review in critically ill patients. Good Clinical Research Practice (GCRP) was evaluated. Good Clinical Research Practice (GCRP) guidelines can be integrated into intensive care unit research projects as routine with a minimum of extra time and effort.
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