Key result
Lower estrogen and elevated hs-CRP and MMP-9 strongly correlate with more stenosed coronary vessels.
Why the study?
The correlation between the severity of coronary artery lesions in ACS patients and levels of estrogen, hs-CRP, and MMP-9 was not well established.
Do serum levels of estrogen, hs-CRP, and MMP-9 correlate with the severity of coronary artery lesions in patients with coronary artery disease?
Cross-Sectional (n=134)
No
Do serum levels of estrogen, hs-CRP, and MMP-9 correlate with the severity of coronary artery lesions in patients with coronary artery disease?
Effect estimate: r=-0.6467 for estrogen, r=0.6519 for hs-CRP, r=0.6835 for MMP-9
p-value: p=<0.05
Serum levels of estrogen, hs-CRP, and MMP-9 significantly correlate with the severity of coronary artery lesions and may serve as biomarkers for evaluating plaque stability.
May support biomarker evaluation of CAD severity; hypothesis-generating and requires prospective validation before clinical use.
The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs-CRP and MMP-9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs-CRP and MMP-9 levels (r=-0.6634 and -0.6878, respectively; both P<0.05). hs-CRP and MMP-9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=-0.6467, P<0.05), and positively correlated with hs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.
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Guo et al. (2014) conducted a cross-sectional in Acute coronary syndrome and stable angina pectoris (n=134). Serum levels of estrogen, hs-CRP, and MMP-9 vs. Healthy controls was evaluated on Correlation between the number of stenosed coronary vessels and serum levels of estrogen, hs-CRP, and MMP-9 (r=-0.6467 for estrogen, r=0.6519 for hs-CRP, r=0.6835 for MMP-9, p=<0.05). The number of stenosed coronary vessels was negatively correlated with serum estrogen levels (r=-0.6467) and positively correlated with hs-CRP (r=0.6519) and MMP-9 levels (r=0.6835).
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