Key result
Cellular daunorubicin metabolism in acute myeloid leukemia cells correlates with CR1 protein expression.
Why the study?
The enzyme responsible for anthracycline metabolism in leukemic cells from AML patients was unknown, despite its potential role in drug resistance.
Population
Mononuclear blood cells isolated at diagnosis from 25 AML patients
Comparison
Daunorubicin metabolism with and without specific CR1 inhibitor zeraleone analogue 5
Design
Preclinical metabolic assay with mRNA and protein expression analysis
Authors
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Variability in daunorubicin metabolism may affect AML response; leaves open CR1 as a predictive biomarker.
Effect estimate: R2 = 0.229
p-value: p=< 0.05
Carbonyl reductase 1 (CR1) is the most important enzyme for the conversion of daunorubicin to daunorubicinol in AML cells, highlighting a potential target for individualizing dosing.
Bogason et al. (2010) studied Acute Myeloid Leukemia (n=25). Carbonyl reductase 1 (CR1) protein expression was evaluated on Correlation between cellular daunorubicin metabolism and CR1 protein expression (R2 = 0.229, p=< 0.05). Cellular daunorubicin metabolism in acute myeloid leukemia cells showed large interindividual variability and correlated significantly with CR1 protein expression (R2 = 0.229, p < 0.05).
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