What is the clinical evidence from this study?

Study design: Other. Population: Non-alcoholic fatty liver disease (NAFLD). Intervention: Inulin. Primary outcome: Bile acids accumulation and excretion.

What does this research mean for the field?

Inulin supplementation attenuates non-alcoholic fatty liver disease in high-fat-induced mice by restoring FXR activity and promoting hepatic bile acid synthesis and excretion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 10, 2022Biochemical and Biophysical Research CommunicationsOpen Access

Inulin activates FXR-FGF15 signaling and further increases bile acids excretion in non-alcoholic fatty liver disease mice

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Key result

Inulin attenuates NAFLD in mice by restoring FXR activity and enhancing bile acid excretion.

Why the study?

Bile acids are disproportionately increased in NAFLD patients while hepatic bile acids signaling is suppressed, and the role of inulin in modulating bile acids signaling in NAFLD is unclear.

Does inulin improve lipid metabolism disorders by modulating bile acids signaling in high-fat-induced NAFLD mice?

Population

High-fat-induced NAFLD mice

Comparison

Inulin treatment vs no treatment

Design

Preclinical study

Authors

RWRui WangWannan Medical College YRYi RenNingxia Medical University TBTing BaoUniversity of Tennessee at Knoxville

Discussion

Member takes

Implication

Hypothesis-generating for inulin in human NAFLD; prospective trials needed before clinical consideration.

Structured PICO

Does inulin improve lipid metabolism disorders by modulating bile acids signaling in high-fat-induced NAFLD mice?

Population

High-fat-induced non-alcoholic fatty liver disease (NAFLD) mice

Intervention

Inulin treatment/supplementation

Comparator

null

Outcome

Reversal of abnormal accumulation of bile acids, restoration of FXR activity, increased hepatic bile acids de novo synthesis, and enhanced bile acids excretionsurrogate

Inulin supplementation attenuates NAFLD in mice by restoring FXR activity and enhancing bile acid synthesis and excretion.

Cite This Study

Wang et al. (2022) studied Non-alcoholic fatty liver disease (NAFLD). Inulin was evaluated on Bile acids accumulation and excretion. Inulin treatment significantly reversed abnormal bile acid accumulation and attenuated NAFLD in high-fat-induced mice by restoring FXR activity and enhancing bile acid excretion.

synapsesocial.com/papers/6aae47b8b01005587e84c7f3 https://doi.org/10.1016/j.bbrc.2022.02.033

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Inulin activates FXR-FGF15 signaling and further increases bile acids excretion in non-alcoholic fatty liver disease mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inulin activates FXR-FGF15 signaling and further increases bile acids excretion in non-alcoholic fatty liver disease mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider