Key result
NPY promoter rs16147 TT genotype is linked to a higher frequency of smoking.
Why the study?
Neuropeptide Y is implicated in tobacco dependence pathophysiology, but the association between its promoter gene variant SNP rs16147 and tobacco smoking was unclear.
Is the TT genotype of SNP rs16147 in the NP-Y promoter gene associated with an increased risk of tobacco smoking in Caucasian subjects?
Case-Control (n=1,094)
Yes
Is the TT genotype of SNP rs16147 in the NP-Y promoter gene associated with an increased risk of tobacco smoking in Caucasian subjects?
p-value: p=0.046
The TT genotype of the NPY promoter gene SNP rs16147 is associated with an increased risk of tobacco dependence and higher state anxiety, suggesting a genetic link to smoking behavior.
TT genotype at rs16147 was associated with higher smoking prevalence; leaves open a genetic role in tobacco dependence pending replication.
BACKGROUND: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. METHODS: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). RESULTS: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). CONCLUSIONS: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.
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Mutschler et al. (2012) conducted a case-control in Tobacco dependence (n=1,094). TT genotype of SNP rs16147 vs. C allele carriers was evaluated on Tobacco smoking status (p=0.046). The TT genotype of the SNP rs16147 in the NPY promoter gene was significantly more frequent in smokers than in never-smokers (p = 0.046).
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