Iron oxide nanoparticles have become widely used today in medical applications. In this study, we report a hyperthermia treatment with 10 and 100 nm naked and polyethylene glycol(PEG)-coated Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) to normal and tumor cells in culture. Cells’ responses to nanoparticles were analyzed by cell viability assays (MTT and LDH) and transmission electron microscopy. Results indicate that even if 10 nm SPIONs have good magnetization saturation, the hyperthermia treatment is not effective due to the fact that cells do not endocytose them. 100 nm SPIONs are better engulfed by cells, and their hyperthermia effect is slightly increased.
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Macavei et al. (2017) studied this question.