New Jersey Agrieultura~ ~xperiment ~tation, SussexSynthalin A decreased bromsulphalein fractional clearance and blood sugar levels, and caused liver damage in Holstein calves, when compared with both normal and starved controls.Hypoglycemia caused by synthalin A may be the result of impairment of gluconeogenic activity of the liver. Editor.Richards and Weaver (10) reported that the injection of synthalin A into immature and mature dairy cattle caused an initial hyperglycemia, followe~t by a marked hypoglycemia in a few hours.These findings may be variously interpreted : (a) The pancreas is the source of a hyperglycemic factor (HGF) (~, 9);(b) synthalin A causes destruction or injury to the alpha cells of the ]slets of Langerhans (3, 5); (c) it causes the disappearance of HGF from the pancreas (6); or (d) it has a toxic effect on the liver (3).Thus, the hypoglycemia fol-
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Mixner et al. (1957) studied this question.
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