Key result
Buffering agent increases milk fat ~31% and lowers lipopolysaccharide levels in lactating goats.
Why the study?
Long-term high-concentrate feeding induces subacute ruminal acidosis and decreases milk fat in lactating goats, and the effect of buffering agents on lipid metabolism and milk fat synthesis is unclear.
Does a buffering agent improve lipid anabolism and milk fat synthesis in lactating goats fed a high-concentrate diet?
Comparison
High-concentrate diet with buffering agent vs high-concentrate diet without buffering agent
Design
Randomized controlled trial
Follow-up
20 weeks
Authors
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Buffering agents may aid milk fat in SARA goats; leaves open hepatic lipid effects pending controlled trials.
RCT (n=12)
Randomly assigned
No
Does a buffering agent improve lipid anabolism and milk fat synthesis in lactating goats fed a high-concentrate diet?
Absolute Event Rate: 4.25% vs 3.24%
p-value: p=<0.05
A buffering agent increases milk fat and plasma NEFA concentrations via the INS-PI3K/AKT/SREBP-1c signaling pathway in lactating goats fed a high-concentrate diet.
LI et al. (2018) conducted an RCT in Subacute ruminal acidosis (SARA) (n=12). Buffering agent (sodium butyrate and sodium bicarbonate) vs. High-concentrate diet (Concentrate:Forage=60:40) was evaluated on Milk fat content (%) (p=<0.05). A buffering agent containing sodium butyrate and sodium bicarbonate significantly increased milk fat content (4.25% vs. 3.24%) and decreased lipopolysaccharide levels in lactating goats fed a high-concentrate diet.
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