Key result
Gothic arch geometry after coarctation repair is linked to greater carotid stiffness and endothelial dysfunction.
Why the study?
The influence of aortic arch geometry on vascular abnormalities after anatomically successful coarctation of the aorta repair was unknown.
Does aortic arch geometry influence vascular remodeling and arterial stiffness in survivors of successful coarctation of the aorta repair?
Observational (n=126)
Does aortic arch geometry influence vascular remodeling and arterial stiffness in survivors of successful coarctation of the aorta repair?
p-value: p=<0.001
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“This team from Padua seems to present the hypothesis that aortic arch geometry influences the incidence of hypertension and its adverse correlations as an established fact. This hypothesis should be viewed as still controversial, as four other teams who have tested this hypothesis have failed to demonstrate its veracity.”
A Gothic aortic arch geometry after successful coarctation repair is associated with adverse vascular remodeling and increased arterial stiffness, highlighting the importance of arch shape in long-term outcomes.
Ou et al. (2007) conducted an observational in Coarctation of the aorta (CoA) (n=126). Gothic aortic arch geometry vs. Crenel and Romanesque geometries and control subjects was evaluated on Carotid artery intima-media thickness (IMT), stiffness index, distensibility, and brachial artery reactivity (p=<0.001). A Gothic aortic arch geometry after coarctation repair was associated with higher carotid IMT and stiffness, and lower distensibility and brachial reactivity compared with other geometries (p<0.001).
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