What question did this study set out to answer?

To evaluate the efficacy and safety of antidepressants, particularly duloxetine and amitriptyline, in managing chemotherapy-induced peripheral neuropathy pain.

September 17, 2026Pharmacology Research & PerspectivesOpen Access

The Role of the Antidepressants in Managing Chemotherapy‐Induced Neuropathic Pain: A Systematic Review

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To evaluate the efficacy and safety of antidepressants, particularly duloxetine and amitriptyline, in managing chemotherapy-induced peripheral neuropathy pain.
Conducted a systematic review following PRISMA guidelines and registered in PROSPERO (CRD42024608551).
Searched PubMed, Scopus, and Web of Science for clinical and observational studies published between November 2019 and October 2025.
Screened 892 records to identify 11 eligible studies evaluating adult patients with chemotherapy-induced peripheral neuropathy.
Duloxetine demonstrated clinically meaningful reductions in neuropathic pain severity based on visual analogue scale, numerical rating scale, and CTCAE pain assessments.
Topical amitriptyline and combination regimens with agents like tapentadol, pregabalin, or mirogabalin reduced pain, though evidence remains insufficient to establish synergy or preventive efficacy.
Antidepressant therapy was generally well tolerated across studies, with adverse events being predominantly mild and manageable.

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Implication

Systematic review reveals antidepressants like duloxetine reduce neuropathic pain in cancer patients, highlighting their clinical value for chemotherapy-induced neuropathy.

Cite This Study

Caminiti et al. (2026) studied this question.

synapsesocial.com/papers/6aae52e262d029e66bf22592 https://doi.org/10.1002/prp2.70327

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Implication

Systematic review reveals antidepressants like duloxetine reduce neuropathic pain in cancer patients, highlighting their clinical value for chemotherapy-induced neuropathy.

The Role of the Antidepressants in Managing Chemotherapy‐Induced Neuropathic Pain: A Systematic Review

Key Points

Discussion

Implication

Cite This Study

The Role of the Antidepressants in Managing Chemotherapy‐Induced Neuropathic Pain: A Systematic Review

Key Points

Discussion

Implication

Cite This Study

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