Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Outcome in adult precursor B-cell acute lymphoblastic leukemia (BCP-ALL) is unsatisfactory, with complete response rates of approximately 80% and event-free survival at 5 years of only 40%–50%.[1][1] This inferior survival in adult compared with pediatric patients might be explained by a higher