Key result
Ankle SBP correlates more strongly with CVD and T2DM than brachial SBP.
Why the study?
The value of absolute ankle systolic blood pressure compared to brachial systolic blood pressure for predicting type 2 diabetes and cardiovascular disease was not known.
Does ankle systolic blood pressure measurement improve the identification of Type 2 diabetes and cardiovascular disease risk compared to brachial blood pressure in adults?
Cross-Sectional (n=1,087)
No
Does ankle systolic blood pressure measurement improve the identification of Type 2 diabetes and cardiovascular disease risk compared to brachial blood pressure in adults?
Ankle systolic blood pressure may be superior to brachial blood pressure for identifying the risk of Type 2 diabetes and cardiovascular diseases, particularly in South Asian populations.
Ankle systolic BP was independently associated with T2DM beyond brachial measures; leaves open whether it improves prediction or warrants clinical adoption in diverse populations.
Increased brachial systolic blood-pressure (BP) predicts diabetes (T2DM) but is not fully effective. Value of absolute ankle systolic BP for T2DM compared to brachial systolic BP is not known. Our objectives were to assess independent relationships of ankle-systolic BP with T2DM and cardiovascular disease in Europeans and south Asians. Cross-sectional studies of anonymised data from registered adults (n = 1087) at inner city deprived primary care practices. Study includes 63.85% ethnic minority. Systolic BP of the left and right-brachial, posterior-tibial and dorsalis-pedis-arteries measured using a Doppler probe. Regression models' factors were age, sex, ethnicity, body mass index (BMI) and waist height ratio (WHtR). Both brachial and ankle systolic-BP increase with diabetes in Europeans and south Asians. We demonstrated that there was a significant positive independent association of ankle BP with diabetes, regardless of age and sex compared to Brachial. There was stronger negative association of ankle blood pressure with cardiovascular disease, after adjustment for BMI, WHtR and ethnicity. Additionally, we found that ankle BP were significantly associated with cardiovascular disease in south Asians more than the Europeans; right posterior tibial. Ankle systolic BPs are superior to brachial BPs to identify risks of Type 2DM and cardiovascular diseases for enhanced patient care.
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Viswambharan et al. (2021) conducted a cross-sectional in Type 2 Diabetes and Cardiovascular Disease (n=1,087). Ankle systolic blood pressure vs. Brachial systolic blood pressure was evaluated on Association of right posterior tibial systolic blood pressure with cardiovascular disease status (adjusted for age, sex, BMI, waist height ratio, and ethnicity) (B -7.12, 95% CI -11.62 to -2.61, p=0.002). Ankle systolic blood pressure demonstrated a stronger independent negative association with cardiovascular disease (MD -7.12) and a positive association with type 2 diabetes compared to brachial blood pressure.
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