Key result
Arid2-IR knockdown reduces glucose-induced Col1a1 and α-SMA expression, blunting Egr1-driven matrix production in diabetic kidneys.
Why the study?
The effect of early growth response protein-1 on long noncoding RNA Arid2-IR in the development of diabetic kidney disease was unknown.
Population
Mice with high-fat diet and streptozotocin-induced type 2 diabetes and mouse mesangial cells cultured with high glucose
Comparison
Knockdown of Arid2-IR and overexpression of Egr1
Design
Preclinical experimental study
Authors
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Arid2-IR may mediate diabetic kidney fibrosis; leaves open translation to human therapy or clinical trials.
Egr1 promotes extracellular matrix production in diabetic kidney disease partly by upregulating the long noncoding RNA Arid2-IR, suggesting Arid2-IR as a potential therapeutic target.
Yang et al. (2018) studied Diabetic kidney disease. Arid2-IR knockdown was evaluated on Expression levels of Col1a1 and α-SMA. Knockdown of Arid2-IR reduced high glucose-induced expression of Col1a1 and α-SMA, suggesting Egr1 promotes extracellular matrix production in diabetic kidney disease partly by upregulating Arid2-IR.
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