Key result
Elevated oxidative stress and lower antioxidants are linked to poor surgical recovery, infections, and mortality.
Why the study?
Oxidative stress is a key biological mechanism influencing surgical recovery, but evidence synthesis on validated oxidative stress biomarkers and postoperative outcomes was lacking.
Are validated oxidative stress biomarkers associated with postoperative outcomes in adult surgical patients?
Comparison
Validated oxidative stress biomarkers and antioxidant-based interventions
Design
Umbrella review of systematic reviews and meta-analyses
Authors
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OS biomarkers may refine perioperative risk stratification; extends evidence for targeted antioxidant trials in high-risk surgical patients.
Systematic Review
Are validated oxidative stress biomarkers associated with postoperative outcomes in adult surgical patients?
Oxidative stress biomarkers show consistent associations with postoperative complications and recovery, highlighting their potential prognostic value in surgical patients.
Cuevas‐Budhart et al. (2025) conducted a systematic review in Postoperative outcomes in adult surgical patients. Oxidative stress biomarkers was evaluated on Postoperative outcomes (infectious complications, impaired healing, cardiovascular events, mortality). Elevated oxidative stress biomarkers (MDA, 8-OHdG) and lower antioxidant levels (TAC, GSH, SOD) were consistently associated with poor surgical recovery, infectious complications, and mortality.
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