What question did this study set out to answer?

To evaluate the relative contributions of tumour necrosis factor (TNF) and HLA-DRB1 polymorphisms to genetic susceptibility to systemic lupus erythematosus (SLE) through extended haplotype analysis.

April 1, 2005Scandinavian Journal of Rheumatology

Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA‐DR3

View Full Paper

Ask AI

Bookmark

Authors

HSHenri SchotteCentre Hospitalier de Luxembourg PWP. WillekeUniversity Hospital Münster NTNicola TidowCedars-Sinai Medical Center

Discussion

Member takes

Implication

Genetic association study reveals tumor necrosis factor polymorphisms confer susceptibility to systemic lupus erythematosus independently of HLA-DR3, highlighting distinct genetic risk profiles.

Key Points

To evaluate the relative contributions of tumour necrosis factor (TNF) and HLA-DRB1 polymorphisms to genetic susceptibility to systemic lupus erythematosus (SLE) through extended haplotype analysis.
Assessed 205 unrelated German Caucasian SLE patients meeting revised ACR criteria and 157 age-, sex-, and ethnically-matched healthy controls.
Typed HLA-DRB1 using sequence-specific oligonucleotide hybridization, and evaluated two TNF SNPs and two microsatellites using mutagenically separated PCR or fragment length analysis.
Reconstructed extended haplotypes using PHASE software to dissect linked genetic effects.
Allele distributions differed significantly between patients and controls, with risk alleles HLA-DR2, DR3, TNFd1, TNF2, TNFB*1, and TNFa2—and haplotypes DR3-TNFd1-TNF2-TNFB*1-TNFa2 and DR2-TNFd3-TNF1-TNFB*2-TNFa11—prevailing in SLE.
TNF risk alleles linked strongly with HLA-DR3, whereas HLA-DR2 conferred SLE risk independently of TNF variants, though risk escalated when TNF risk alleles were present.
In haplotypes lacking both HLA-DR2 and HLA-DR3, alleles TNFd1 and TNF2 contributed independently to SLE susceptibility.

Cite This Study

Schotte et al. (2005) studied this question.

synapsesocial.com/papers/6aaf2cb057c419f6dedc989d https://doi.org/10.1080/03009740510017724

View Full Paper

Ask AI

Bookmark

Implication

Genetic association study reveals tumor necrosis factor polymorphisms confer susceptibility to systemic lupus erythematosus independently of HLA-DR3, highlighting distinct genetic risk profiles.

Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA‐DR3

Discussion

Member takes

Implication

Key Points

Cite This Study

Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA‐DR3

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider