Key result
Elevated serum homocysteine is linked to recurrent abortions, present in ~57% of cases, but not pre-eclampsia.
Why the study?
Hyperhomocysteinaemia is associated with adverse pregnancy outcomes including spontaneous abortion, placental vasculopathy, and birth defects, but its role as a biochemical marker in obstetrical complications requires evaluation.
Does elevated serum homocysteine associate with specific obstetrical complications in pregnant women?
Observational (n=100)
No
Does elevated serum homocysteine associate with specific obstetrical complications in pregnant women?
p-value: p=<0.001
Elevated serum homocysteine is significantly associated with recurrent abortions, highlighting its potential role as a biomarker for adverse pregnancy outcomes.
Warrants homocysteine monitoring in high-risk pregnancies; leaves open whether intervention improves outcomes.
Low plasma homocysteine level during an uncomplicated pregnancy was first demonstrated by Kang et al almost 20 years ago, & this has subsequently been confirmed by numerous investigators. Plasma homocysteine concentrations are 30-60% lower in pregnant women than in non-pregnant women & the lowest levels are observed in the second trimester. Hyperhomocysteinaemia is associated with adverse pregnancy outcome, such as spontaneous early abortion, placental vasculopathy and birth defects. It is not only neural tube defects (NTDs) but also cardiac malformations and cleft lip and/or palate etc. Objective of study is to observe role of Homocysteine as a biochemical marker in various obstetrical complications and to evaluate Homocysteine as a risk factor in obstetrical complications. ADVIA- Centaur equipment is used and method is Chemiluminescence. It has been found that Pre-eclampsia cases have got higher Probabilities of having raised Homocysteine as compared to non-Pre-eclamptic cases, on the other hand Recurrent abortions has been found to be associated with high Homocysteine, indicating adverse effect of Hyperhomocystenemia.
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Baghel et al. (2022) conducted an observational in Obstetrical complications (n=100). Elevated serum homocysteine vs. Normal serum homocysteine was evaluated on Association of elevated serum homocysteine with recurrent abortions (p=<0.001). Elevated serum homocysteine was significantly associated with recurrent abortions, being present in 56.5% of cases (p<0.001), whereas its association with pre-eclampsia was not statistically significant.
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