Key result
Sporadic late-onset nemaline myopathy develops in a 62-year-old male without typical MGUS or HIV associations.
Why the study?
SLONM is a rare acquired myopathy with limited case reports and series, especially distinct from congenital nemaline myopathy.
Case Report (n=1)
No
SLONM should be considered in the differential diagnosis of progressive proximal muscle weakness in adults, even without associated conditions like MGUS or HIV.
SLONM case without typical associations expands known spectrum; leaves open questions on etiology and management in atypical patients.
Sporadic late onset nemaline myopathy (SLONM) is a rare, intractable acquired myopathy that is characterised by progressive muscle weakness and the presence of nemaline rods in myofibres. Unlike the congenital form of nemaline myopathy (NM), there are only few case reports and series on SLONM in the scientific literature. We present a case report of SLONM in a 62-year-old male from a rural town in Western Australia, without any of the conditions often associated with SLONM such as monoclonal gammopathy of uncertain significance or HIV infection. SLONM should be considered in the differential diagnosis of progressive proximal muscle weakness in an adult. Cite this article as: Paramalingam S, Dyke JM, Nossent JC. Sporadic late onset nemaline myopathy (SLONM) in an adult presenting with progressive muscle weakness. Eur J Rheumatol 2019; 6(2): 103-5.
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Paramalingam et al. (2018) conducted a case report in Sporadic late onset nemaline myopathy (SLONM) (n=1). A 62-year-old male presented with sporadic late onset nemaline myopathy without commonly associated conditions like MGUS or HIV infection.
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